Download Nucleic Acid Structure: Understanding RNArchitecture Database

The classification of non-coding RNAs (ncRNAs) is a crucial aspect of molecular biology, and the RNArchitecture database offers a unique platform for storing RNA 3D structure predictions and theoretical models. Unlike other databases, RNArchitecture focuses on structure-based classification of RNA families, providing a comprehensive description of relationships between known structured ncRNA families with an emphasis on structural similarities.

The database's hierarchical organization mirrors that of protein structures in the SCOP and CATH databases. The highest level, Class, categorizes Families into broad structural categories such as simple or complex structured RNAs. Architectures further group similar structures together, while Superfamilies unite evolutionarily related Families. For each Family with experimentally determined 3D structure(s), a representative model is provided.

The database also allows users to submit their own structural models and provides reduced secondary structure representations for consensus structures of Families. The central level, Family, builds upon the Rfam catalog and gathers closely related RNAs.

A fundamental aspect of understanding nucleic acid structure is the difference between proteins and RNA molecules. While proteins consist of 20 different amino acids, nucleic acids are composed of only four types of nucleotides (adenine, guanine, cytosine, and uracil). This simplicity in composition belies the complexity of their structures and functions.

The primary structure of a nucleic acid is defined by its sequence of nucleotides. A similar segment of RNA would have OH groups on each C2', with uracil replacing thymine. By studying the relationships between structured ncRNA families, researchers can gain valuable insights into the evolutionary pressures that have shaped these molecules and their functions.

In conclusion, RNArchitecture is a powerful tool for understanding the structure and classification of non-coding RNA families. Its unique focus on structure-based classification and open submission policy make it an essential resource for researchers in the field of molecular biology.

Download nucleic acid structure